Shed-blood-separation and Cell-Saver: An Integral Part of MiECC? Shed-blood-separation and its Influence on the Perioperative Inflammatory Response During Coronary Revascularization with Minimal Invasive Extracorporeal Circulation Systems- a Randomized Controlled Trial.
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"The postoperative systemic inflammatory response after cardiopulmonary bypass (CPB) is still an undesirable side-effect after cardiac surgery. It is most likely caused by blood contact with foreign surfaces and by the surgical trauma itself. However, the recirculation of activated shed mediastinal blood is another main cause of blood cell activation and cytokine release. Minimal invasive extracorporeal circulation (MiECC) comprises a completely closed circuit, coated surfaces and the separation of suction blood. We hypothesized that MiECC, with separated cell saved blood, would induce less of a systemic inflammatory response than MiECC with no cell-saver. The aim of this study was, therefore, to investigate the impact of cell washing shed blood from the operating field versus direct return to the ECC on the biomarkers for systemic inflammation."1
1. Bauer A, Hausmann H, Schaarschmidt J, Scharpenberg M, Troitzsch D et al. Perfusion. 2017 Sep 1. [Epub ahead of print]