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"Prevention strategies have long been sought to reduce the incidence and burden of postoperative atrial fibrillation (POAF) after heart surgery. However, none has emerged as a dominant and widely applicable prophylactic measure. The purpose of this review is to consider the biological mechanisms by which shed mediastinal blood leads to oxidation and inflammation within the postoperative pericardial environment and how this might trigger POAF in susceptible persons, as well as how it could represent a new target for prevention of POAF."1
1. Pericardial Blood as a Trigger for Postoperative Atrial Fibrillation After Cardiac Surgery.
St-Onge S, Perrault LP, Demers P, Boyle EM, Gillinov AM et al.
Ann Thorac Surg. 2018 Jan;105(1):321-328