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Background: "Perinatal and perioperative brain injury is a fundamental problem in infants with severe congenital heart disease undergoing neonatal cardiac surgery with cardiopulmonary bypass. An impaired neuromotor and neurocognitive development is encountered and associated with a reduction in quality of life. New neuroprotective drugs during surgery are described to reduce brain injury and improve neurodevelopmental outcome. Therefore, our aim was to provide a systematic review and best-evidence synthesis on the effects of neuroprotective drugs on brain injury and neurodevelopmental outcome in congenital heart disease infants requiring cardiac surgery with cardiopulmonary bypass."1
1. Neuroprotective Drugs in Infants With Severe Congenital Heart Disease: A Systematic Review.
Stegeman R, Lamur KD, van den Hoogen A, Breur JMPJ, Groenendaal F et al.
Front Neurol. 2018 Jul 3;9:521 FREE