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"MTB should be considered during vasoplegic syndrome in cardiac surgery with cardiopulmonary bypass and usage may be more effective in an early critical window, prior to end-organ hypoperfusion. Other perioperative scenarios of MTB use show promise, but additional studies are required to develop formative conclusions."1
1. Intraoperative vasoplegia: methylene blue to the rescue!
McCartney SL, Duce L, Ghadimi K.
Curr Opin Anaesthesiol. 2017 Nov 15. [Epub ahead of print]