Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass.

Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass

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Objectives:
"Although clinical practice guidelines recommend standard cefazolin antimicrobial prophylaxis (AP) dosing for cardiac surgery, limited data exist as to whether adequate concentrations are achieved in this patient population. The goal of our study was to characterize intraoperative cefazolin concentrations particularly at wound closure with regards to maintaining target cefazolin closure concentrations ≥40 mg/L."1


1. Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass.
Calic D, Ariano RE, Arora RC, Grocott HP, Lakowski TM et al.
J Antimicrob Chemother. 2017 Dec 8. [Epub ahead of print]

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